Thioridazine Monosulfoxide Analog en es it fr

Thioridazine Monosulfoxide Analog Brand names, Thioridazine Monosulfoxide Analog Analogs

Thioridazine Monosulfoxide Analog Brand Names Mixture

  • No information avaliable

Thioridazine Monosulfoxide Analog Chemical_Formula

C21H26N2OS2

Thioridazine Monosulfoxide Analog RX_link

http://www.rxlist.com/cgi/generic3/mesoridazine.htm

Thioridazine Monosulfoxide Analog fda sheet

Thioridazine Monosulfoxide Analog msds (material safety sheet)

Thioridazine Monosulfoxide Analog Synthesis Reference

No information avaliable

Thioridazine Monosulfoxide Analog Molecular Weight

386.576 g/mol

Thioridazine Monosulfoxide Analog Melting Point

No information avaliable

Thioridazine Monosulfoxide Analog H2O Solubility

No information avaliable

Thioridazine Monosulfoxide Analog State

Solid

Thioridazine Monosulfoxide Analog LogP

4.485

Thioridazine Monosulfoxide Analog Dosage Forms

Tablet (10 mg, 25 mg, 50 mg, 100 mg) for oral administration; Ampuls (1 mL) for intramuscular administration; Concentrate for oral administration

Thioridazine Monosulfoxide Analog Indication

Used in the treatment of schizophrenia, organic brain disorders, alcoholism and psychoneuroses.

Thioridazine Monosulfoxide Analog Pharmacology

Mesoridazine, the besylate salt of a metabolite of thioridazine, is a phenothiazine tranquilizer. Pharmacological studies in laboratory animals have established that mesoridazine has a spectrum of pharmacodynamic actions typical of a major tranquilizer. In common with other tranquilizers it inhibits spontaneous motor activity in mice, prolongs thiopental and hexobarbital sleeping time in mice and produces spindles and block of arousal reaction in the EEG of rabbits. It is effective in blocking spinal reflexes in the cut and antagonizes d-amphetamine excitation and toxicity in grouped mice. It shows a moderate adrenergic blocking activity in vitro and in vivo and antagonizes 5-hydroxytryptamine in vivo. Intravenously administered, it lowers the blood pressure of anesthetized dogs. It has a weak antiacetylcholine effect in vitro.

Thioridazine Monosulfoxide Analog Absorption

Well absorbed from the gastrointestinal tract.

Thioridazine Monosulfoxide Analog side effects and Toxicity

Oral LD50 is 560 ± 62.5 mg/kg and 644 ± 48 mg/kg in mouse and rat, respectively. Symptoms of overdose may include emesis, muscle tremors, decreased food intake and death associated with aspiration of oral-gastric contents into the respiratory system.

Thioridazine Monosulfoxide Analog Patient Information

Thioridazine Monosulfoxide Analog Organisms Affected

Humans and other mammals