Thilatazin en es it fr

Thilatazin Brand names, Thilatazin Analogs

Thilatazin Brand Names Mixture

  • Apo Peram Tab 2-25 (Amitriptyline Hydrochloride + Perphenazine)
  • Apo Peram Tab 3-15 (Amitriptyline Hydrochloride + Perphenazine)
  • Elavil Plus Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon 2 10 (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon a Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon D Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Etrafon F Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 2/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 3/15 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Pms-Levazine 4/25 Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Proavil Tab (Amitriptyline Hydrochloride + Perphenazine)
  • Triavil Tab (Amitriptyline Hydrochloride + Perphenazine)

Thilatazin Chemical_Formula

C21H26ClN3OS

Thilatazin RX_link

http://www.rxlist.com/cgi/generic3/perphenazine.htm

Thilatazin fda sheet

Thilatazin FDA

Thilatazin msds (material safety sheet)

Thilatazin MSDS

Thilatazin Synthesis Reference

Cusic, U.S. pat. 2860138

Thilatazin Molecular Weight

403.969 g/mol

Thilatazin Melting Point

97 oC

Thilatazin H2O Solubility

28.3 mg/L

Thilatazin State

Solid

Thilatazin LogP

4.176

Thilatazin Dosage Forms

Liquid; Solution; Syrup; Tablet (2, 4, 8, or 16 mg)

Thilatazin Indication

For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults.

Thilatazin Pharmacology

Perphenazine is a piperazinyl phenothiazine, acts on the central nervous system, and has a greater behavioral potency than other phenothiazine derivatives whose side chains do not contain a piperazine moiety. It is a member of a class of drugs called phenothiazines, which are dopamine D1/D2 receptor antagonists. Perphenazine is 10 to 15 times as potent as chlorpromazine; that means perphenazine is a highly potent antipsychotic. In equivalent doses it has approximately the same frequency and severity of early and late extrapypramidal side-effects compared to Haloperidol.

Thilatazin Absorption

Absolute bioavailability is 40% following oral administration.

Thilatazin side effects and Toxicity

Symptoms of overdose include stupor or coma, and children may have convulsive seizures. Signs of arousal may not occur for 48 hours. Oral LD50=318 mg/kg (rat); IPR LD50=64 mg/kg (mouse)

Thilatazin Patient Information

This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.

Given the likelihood that a substantial proportion of patients exposed chronically to neuroleptics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.

Thilatazin Organisms Affected

Humans and other mammals