Thiabendazole
Thiabendazole Brand names, Thiabendazole Analogs
Thiabendazole Brand Names Mixture
- No information avaliable
Thiabendazole Chemical_Formula
C10H7N3S
Thiabendazole RX_link
http://www.rxlist.com/cgi/generic2/thiabendazole.htm
Thiabendazole fda sheet
Thiabendazole msds (material safety sheet)
Thiabendazole Synthesis Reference
No information avaliable
Thiabendazole Molecular Weight
201.249 g/mol
Thiabendazole Melting Point
300 oC
Thiabendazole H2O Solubility
Practically insoluble (50 mg/L at pH 7, 10 at 20°C)
Thiabendazole State
Solid
Thiabendazole LogP
1.613
Thiabendazole Dosage Forms
Tablets (500 mg chewable); Suspension (containing 500 mg thiabendazole per 5 mL)
Thiabendazole Indication
For the treatment of strongyloidiasis (threadworm), cutaneous larva migrans (creeping eruption), visceral larva migrans, and trichinosis.
Thiabendazole Pharmacology
Thiabendazole is a fungicide and parasiticide. Thiabendazole is also a chelating agent, which means that it is used medicinally to bind metals in cases of metal poisoning, such as lead poisoning, mercury poisoning or antimony poisoning. Thiabendazole is vermicidal and/or vermifugal against Ascaris lumbricoides ("common roundworm"), Strongyloides stercoralis (threadworm), Necator americanus, Ancylostoma duodenale (hookworm), Trichuris trichiura (whipworm), Ancylostoma braziliense (dog and cat hookworm), Toxocara canis, Toxocara cati (ascarids), and Enterobius vermicularis (pinworm). Thiabendazole also suppresses egg and/or larval production and may inhibit the subsequent development of those eggs or larvae which are passed in the feces.
Thiabendazole Absorption
Rapidly absorbed and peak plasma concentration is reached within 1 to 2 hours after the oral administration of a suspension. Some systemic absorption may occur from topical preparations applied to the skin.
Thiabendazole side effects and Toxicity
Overdosage may be associated with transient disturbances of vision and psychic alterations. The oral LD 50 is 3.6 g/kg, 3.1 g/kg and 3.8 g/kg in the mouse, rat, and rabbit respectively.
Thiabendazole Patient Information
Thiabendazole Organisms Affected
Roundworms, hookworms, and other helminth species
