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Thecodine Brand names, Thecodine Analogs

Thecodine Brand Names Mixture

  • Combunox
  • ENDOCET
  • PERCOCET
  • ENDODAN
  • Percodan-Demi (Acetylsalicylic Acid + Oxycodone Hydrochloride)
  • Pms-Oxycodone - Acetaminophen (Acetaminophen + Oxycodone (Oxycodone Hydrochloride))
  • Rivacocet (Acetaminophen + Oxycodone (Oxycodone Hydrochloride))
  • Roxicet Tab (Acetaminophen + Oxycodone Hydrochloride)

Thecodine Chemical_Formula

C18H21NO4

Thecodine RX_link

http://www.rxlist.com/cgi/generic2/oxyco.htm

Thecodine fda sheet

Thecodine FDA

Thecodine msds (material safety sheet)

Thecodine MSDS

Thecodine Synthesis Reference

Small, Lutz, "Chemistry of the Opium Alkaloids", Suppl.No.103 (1932)

Thecodine Molecular Weight

315.364 g/mol

Thecodine Melting Point

218-220 oC

Thecodine H2O Solubility

100 mg/ml

Thecodine State

Solid

Thecodine LogP

0.993

Thecodine Dosage Forms

Tablet; Suppository

Thecodine Indication

For the treatment of diarrhoea, pulmonary oedema; For the relief of moderate to moderately severe pain

Thecodine Pharmacology

Oxycodone, a semisynthetic opiate agonist derived from the opioid alkaloid, thebaine, is similar to other phenanthrene derivatives such as hydrocodone and morphine. Oxycodone is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.

Thecodine Absorption

well absorbed from OxyContinĀ® tablets with an oral bioavailability of 60% to 87%

Thecodine side effects and Toxicity

respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypotension, and death.

Thecodine Patient Information

WARNINGS

Drug Dependence: Oxycodone can produce drug dependence of the morphine type, and therefore, has the potential for being abused. Psychic dependence, physical dependence and tolerance may develop upon repeated administration of this drug, and it should be prescribed and administered with the same degree of caution appropriate to the use of other oral narcotic-containing medications. Like other narcotic-containing medications, this drug is subject to the Federal Controlled Substances Act.

Usage in Ambulatory Patients: Oxycodone may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery. The patient using this drug should be cautioned accordingly.

Interaction with Other Central Nervous System Depressants: Patients receiving other narcotic analgesics, general anesthetics, phenothiazines, other tranquilizers, sedative-hypnotics or other CNS depressants (including alcohol) concomitantly with oxycodone hydrochloride may exhibit an additive CNS depression. When such combined therapy is contemplated, the dose of one or both agents should be reduced.

Usage in Pregnancy: Safe use in pregnancy has not been established relative to possible adverse effects on fetal development. Therefore, this drug should not be used in pregnant women unless, in the judgment of the physician, the potential benefits outweigh the possible hazards.

Usage in Children: This drug should not be administered to children.

PRECAUTIONS

Head Injury and Increased Intracranial Pressure: The respiratory depressant effects of narcotics and their capacity to elevate cerebrospinal fluid pressure may be markedly exaggerated in the presence of head injury, other intracranial lesions or a pre-existing increase in intracranial pressure. Furthermore, narcotics produce adverse reactions which may obscure the clinical course of patients with head injuries.

Acute Abdominal Conditions: The administration of this drug or other narcotics may obscure the diagnosis or clinical course in patients with acute abdominal conditions.

Special Risk Patients: This drug should be given with caution to certain patients such as the elderly, or debilitated, and those with severe impairment of hepatic or renal function, hypothyroidism, Addison's disease and prostatic hypertrophy or urethral stricture.

Thecodine Organisms Affected

Humans and other mammals