Tevcocin
Category
Tevcocin Brand names, Tevcocin Analogs
Tevcocin Brand Names Mixture
Tevcocin Chemical_Formula
C11H12Cl2N2O5
Tevcocin RX_link
http://www.rxlist.com/cgi/generic3/chloramphenicol.htm
Tevcocin fda sheet
Tevcocin msds (material safety sheet)
Tevcocin Synthesis Reference
No information avaliable
Tevcocin Molecular Weight
323.129 g/mol
Tevcocin Melting Point
150.5 oC
Tevcocin H2O Solubility
2500 mg/L (at 25 °C)
Tevcocin State
Solid
Tevcocin LogP
1.476
Tevcocin Dosage Forms
Capsule; Drops; Liquid; Ointment; Powder; Solution; Suspension; Tablet
Tevcocin Indication
Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.
Tevcocin Pharmacology
Chloramphenicol is a broad-spectrum antibiotic that was derived from the bacterium Streptomyces venezuelae and is now produced synthetically. Chloramphenicol is effective against a wide variety of microorganisms, but due to serious side-effects (e.g., damage to the bone marrow, including aplastic anemia) in humans, it is usually reserved for the treatment of serious and life-threatening infections (e.g., typhoid fever). Chloramphenicol is bacteriostatic but may be bactericidal in high concentrations or when used against highly susceptible organisms. Chloramphenicol stops bacterial growth by binding to the bacterial ribosome (blocking peptidyl transferase) and inhibiting protein synthesis.
Tevcocin Absorption
Rapidly and completely absorbed from gastrointestinal tract following oral administration (bioavailability 80%). Well absorbed following intramuscular administration (bioavailability 70%). Intraocular and some systemic absorption also occurs after topical application to the eye.
Tevcocin side effects and Toxicity
Oral, mouse: LD50 = 1500 mg/kg; Oral, rat: LD50 = 2500 mg/kg. Toxic reactions including fatalities have occurred in the premature and newborn; the signs and symptoms associated with these reactions have been referred to as the gray syndrome. Symptoms include (in order of appearance) abdominal distension with or without emesis, progressive pallid cyanosis, vasomotor collapse frequently accompanied by irregular respiration, and death within a few hours of onset of these symptoms.
Tevcocin Patient Information
No information avaliable
Tevcocin Organisms Affected
Enteric bacteria and other eubacteria
