Tetrahydroaminacrine
Tetrahydroaminacrine Brand names, Tetrahydroaminacrine Analogs
Tetrahydroaminacrine Brand Names Mixture
- No information avaliable
Tetrahydroaminacrine Chemical_Formula
C13H14N2
Tetrahydroaminacrine RX_link
http://www.rxlist.com/cgi/generic2/tacrine.htm
Tetrahydroaminacrine fda sheet
Tetrahydroaminacrine msds (material safety sheet)
Tetrahydroaminacrine Synthesis Reference
No information avaliable
Tetrahydroaminacrine Molecular Weight
198.264 g/mol
Tetrahydroaminacrine Melting Point
183.5 oC
Tetrahydroaminacrine H2O Solubility
217 mg/L
Tetrahydroaminacrine State
Solid
Tetrahydroaminacrine LogP
2.298
Tetrahydroaminacrine Dosage Forms
No information avaliable
Tetrahydroaminacrine Indication
For the treatment of mild to moderate dementia of the Alzheimer's type.
Tetrahydroaminacrine Pharmacology
Tacrine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Tacrine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process.
Tetrahydroaminacrine Absorption
Tacrine is rapidly absorbed. Absolute bioavailability of tacrine is approximately 17 ± 13%.
Tetrahydroaminacrine side effects and Toxicity
No information avaliable
Tetrahydroaminacrine Patient Information
No information avaliable
Tetrahydroaminacrine Organisms Affected
Humans and other mammals
