Tertensif
Category
Tertensif Brand names, Tertensif Analogs
Tertensif Brand Names Mixture
Tertensif Chemical_Formula
C16H16ClN3O3S
Tertensif RX_link
http://www.rxlist.com/cgi/generic/indap.htm
Tertensif fda sheet
Tertensif msds (material safety sheet)
Tertensif Synthesis Reference
No information avaliable
Tertensif Molecular Weight
365.835 g/mol
Tertensif Melting Point
161 oC
Tertensif H2O Solubility
75 mg/L
Tertensif State
Solid
Tertensif LogP
2.088
Tertensif Dosage Forms
Tablet
Tertensif Indication
For the treatment of hypertension, alone or in combination with other antihypertensive drugs as well as for the treatment of salt and fluid retention associated with congestive heart failure or edema from pregnancy.
Tertensif Pharmacology
Indapamide is an antihypertensive and a diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid- soluble methylindoline moiety. Indapamide bears a structural similarity to the triazide diuretics which are known to decrease vascular smooth muscle reactivity. However, it differs chemically from the thiazides in that it does not possess the thiazide ring system and contains only one sulfonamide group. Indapamide appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. This same effect may cause hypokalcemia in susceptible individuals. Indapamide has also been shown to cause uterine myometrial relaxation in experimental animals. Overall, indapamide has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.
Tertensif Absorption
Rapidly absorbed from gastrointestinal tract.
Tertensif side effects and Toxicity
Side effects include electrolyte imbalance (potassium or salt depletion due to too much fluid loss), nausea, stomach disorders, vomiting, weakness
Tertensif Patient Information
No information avaliable
Tertensif Organisms Affected
Humans and other mammals
