Terfex
Category
Terfex Brand names, Terfex Analogs
Terfex Brand Names Mixture
Terfex Chemical_Formula
C32H41NO2
Terfex RX_link
http://www.rxlist.com/cgi/generic/terfen.htm
Terfex fda sheet
Terfex msds (material safety sheet)
Terfex Synthesis Reference
A. A. Carr, C. R. Kinsolving, U.S. Pat. 3,878,217 (1975)
Terfex Molecular Weight
471.673 g/mol
Terfex Melting Point
146.5-148.5oC
Terfex H2O Solubility
10 mg/L
Terfex State
Solid
Terfex LogP
7.784
Terfex Dosage Forms
Oral tablets
Terfex Indication
For the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Terfex Pharmacology
Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine.
Terfex Absorption
On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%
Terfex side effects and Toxicity
Mild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)
Terfex Patient Information
Terfex Organisms Affected
Humans and other mammals
