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Terfenadine en es it fr

Terfenadine Brand names, Terfenadine Analogs

Terfenadine Brand Names Mixture

  • No information avaliable

Terfenadine Chemical_Formula

C32H41NO2

Terfenadine RX_link

http://www.rxlist.com/cgi/generic/terfen.htm

Terfenadine fda sheet

Terfenadine msds (material safety sheet)

Terfenadine Synthesis Reference

A. A. Carr, C. R. Kinsolving, U.S. Pat. 3,878,217 (1975)

Terfenadine Molecular Weight

471.673 g/mol

Terfenadine Melting Point

146.5-148.5oC

Terfenadine H2O Solubility

10 mg/L

Terfenadine State

Solid

Terfenadine LogP

7.784

Terfenadine Dosage Forms

Oral tablets

Terfenadine Indication

For the treatment of allergic rhinitis, hay fever, and allergic skin disorders.

Terfenadine Pharmacology

Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine.

Terfenadine Absorption

On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%

Terfenadine side effects and Toxicity

Mild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)

Terfenadine Patient Information

Terfenadine Organisms Affected

Humans and other mammals