Sulphofurazole
Category
Sulphofurazole Brand names, Sulphofurazole Analogs
Sulphofurazole Brand Names Mixture
- Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
- Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)
Sulphofurazole Chemical_Formula
C11H13N3O3S
Sulphofurazole RX_link
No information avaliable
Sulphofurazole fda sheet
Sulphofurazole msds (material safety sheet)
Sulphofurazole Synthesis Reference
H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)
Sulphofurazole Molecular Weight
267.305 g/mol
Sulphofurazole Melting Point
194 oC
Sulphofurazole H2O Solubility
0.13 mg/ml (25 oC)
Sulphofurazole State
Solid
Sulphofurazole LogP
2.569
Sulphofurazole Dosage Forms
Tablet; Oral suspension; Eye drops
Sulphofurazole Indication
Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Sulphofurazole Pharmacology
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Sulphofurazole Absorption
No information avaliable
Sulphofurazole side effects and Toxicity
LD50=6800 mg/kg (Orally in mice)
Sulphofurazole Patient Information
Sulphofurazole Organisms Affected
Enteric bacteria and other eubacteria
