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Sulfisin Brand names, Sulfisin Analogs

Sulfisin Brand Names Mixture

  • Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
  • Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)

Sulfisin Chemical_Formula

C11H13N3O3S

Sulfisin RX_link

No information avaliable

Sulfisin fda sheet

Sulfisin msds (material safety sheet)

Sulfisin MSDS

Sulfisin Synthesis Reference

H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)

Sulfisin Molecular Weight

267.305 g/mol

Sulfisin Melting Point

194 oC

Sulfisin H2O Solubility

0.13 mg/ml (25 oC)

Sulfisin State

Solid

Sulfisin LogP

2.569

Sulfisin Dosage Forms

Tablet; Oral suspension; Eye drops

Sulfisin Indication

Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.

Sulfisin Pharmacology

Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.

Sulfisin Absorption

No information avaliable

Sulfisin side effects and Toxicity

LD50=6800 mg/kg (Orally in mice)

Sulfisin Patient Information

Sulfisin Organisms Affected

Enteric bacteria and other eubacteria