Spironolactone

• Aldosterone Antagonists
• Diuretics
• ATC:C03DA01

• Rocuronium bromide
• Zemuron

• No information avaliable

C₂₄H₃₂O₄S

http://www.rxlist.com/cgi/generic/spiron.htm

Spironolactone FDA

Spironolactone MSDS

No information avaliable

416.574 g/mol

134.5 ^oC

Practically insoluble (22 mg/L)

Solid

4.308

Oral tablets (25 mg, 50 mg, or 100 mg)

Used primarily to treat low-renin hypertension, hypokalemia, and Conn's syndrome.

Spironolactone is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics. On its own, spironolactone is only a weak diuretic, but it can be combined with other diuretics. Due to its anti-androgen effect, it can also be used to treat hirsutism, and is a common component in hormone therapy for male-to-female transgendered people. Spironolactone inhibits the effect of aldosterone by competing for intracellular aldosterone receptor in the distal tubule cells. This increases the secretion of water and sodium, while decreasing the excretion of potassium. Spironolactone has a fairly slow onset of action, taking several days to develop and similarly the effect diminishes slowly.

Fairly rapidly absorbed from the gastrointestinal tract. Food increases the bioavailability of unmetabolized spironolactone by almost 100%.

The oral LD₅₀ of spironolactone is greater than 1,000 mg/kg in mice, rats, and rabbits. Acute overdosage of spironolactone may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Spironolactone has been shown to be a tumorigen in chronic toxicity studies in rats.

Humans and other mammals