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Spectinomicina [Italian] Brand names, Spectinomicina [Italian] Analogs

Spectinomicina [Italian] Brand Names Mixture

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Spectinomicina [Italian] Chemical_Formula


Spectinomicina [Italian] RX_link


Spectinomicina [Italian] fda sheet

Spectinomicina_[Italian] FDA

Spectinomicina [Italian] msds (material safety sheet)

Spectinomicina_[Italian] MSDS

Spectinomicina [Italian] Synthesis Reference

No information avaliable

Spectinomicina [Italian] Molecular Weight

351.463 g/mol

Spectinomicina [Italian] Melting Point

No information avaliable

Spectinomicina [Italian] H2O Solubility


Spectinomicina [Italian] State


Spectinomicina [Italian] LogP


Spectinomicina [Italian] Dosage Forms

Cream or gel (0.05% or 0.1%)

Spectinomicina [Italian] Indication

Used to treat psoriasis, acne and sun damaged skin (photodamage).

Spectinomicina [Italian] Pharmacology

Tazarotene is a prodrug and a member of the acetylenic class of retinoids. Following topical application, tazarotene undergoes esterase hydrolysis to form its active metabolite, tazarotenic acid. When treating acne tazarotene may be taken in conjunction with an oral antibiotic. Tazarotene has been shown in peer-reviewed double blinded studies to reduce: mottling and hyperpigmentation, sallowness, fine wrinkling and coarse wrinkling in sun damaged skin. Histological studies have shown that long term (greater than 1 year) use of Tazarotene is associated with a significant reduction in atypical melanocytes and keratocytes - cells considered to be precursors of skin cancer. Some studies have shown long term use of Tazarotene to be associated with increased collagen production and better organization of skin collagen bundles.

Spectinomicina [Italian] Absorption

Minimal systemic absorption of tazarotene occurs due to its rapid metabolism in the skin to the active metabolite, tazarotenic acid, which can be systemically absorbed and further metabolized. Gender had no influence on the systemic bioavailability of tazarotenic acid.

Spectinomicina [Italian] side effects and Toxicity

Excessive topical use may lead to marked redness, peeling, or discomfort. Oral ingestion of the drug may affect liver function causing hypertriglyceridemia. Other symptoms may include conjunctival irritation, hair loss, headache, edema, fatigue, dermatitis, nausea, and visual disturbances. Oral administration of this material to rats and rabbits at doses of 0.20 mg/kg/day (rabbits) and 0.25 mg/kg/day (rats) resulted in developmental toxicity. A no effect level of 0.05 mg/kg/day was established. Similar teratogenic effects have been reported for other retinoid compounds.

Spectinomicina [Italian] Patient Information

Spectinomicina [Italian] Organisms Affected

Humans and other mammals