Simendan

Simendan Brand names, Simendan Analogs

Simendan Brand Names Mixture

No information avaliable

Simendan Chemical_Formula

C₁₄H₁₁Cl₂NO₂

Simendan RX_link

http://www.rxlist.com/cgi/generic3/meclofen.htm

Simendan fda sheet

Simendan msds (material safety sheet)

Simendan MSDS

Simendan Synthesis Reference

No information avaliable

Simendan Molecular Weight

295.02 g/mol

Simendan Melting Point

257 ^oC

Simendan H₂O Solubility

30 mg/L

Simendan State

Solid

Simendan LogP

4.998

Simendan Dosage Forms

Capsules (containing 50 mg or 100 mg meclofenamic acid as the sodium salt)

Simendan Indication

For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.

Simendan Pharmacology

Meclofenamate is a nonsteroidal agent which has demonstrated anti-inflammatory, analgesic, and antipyretic activity in laboratory animals.

Simendan Absorption

Rapidly absorbed in man following single and multiple oral doses with peak plasma concentrations occurring in 0.5 to 2 hours. The concomitant administration of antacids (aluminum and magnesium hydroxides) does not interfere with absorption of meclofenamate. Unlike most NSAIDs, which when administered with food have a decrease in rate but not in extent of absorption, meclofenamic acid is decreased in both. It has been reported that following the administration of meclofenamate capsules one-half hour after a meal, the average extent of bioavailability decreased by 26%, the average peak concentration (C_max) decreased fourfold and the time to C_max was delayed by 3 hours.

Simendan side effects and Toxicity