Sildenafil

• Vasodilator Agents
• Phosphodiesterase Inhibitors
• ATC:G04BE03

• Sildenafil Viagra
• Viagra

• No information avaliable

C₂₂H₃₀N₆O₄S

http://www.rxlist.com/cgi/generic/viagra.htm

Sildenafil FDA

Sildenafil MSDS

Nicholas K. Terrett et al., Bioorganic & Medicinal Chemistry Letters, Vol 6, pp. 1819-1824 (1996)

474.578 g/mol

189-190 ^oC

3.5 mg/mL

Solid

No information avaliable

Tablet

For the treatment of erectile dysfunction

Sildenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Sildenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Sildenafil should not cause an erection.

~40%

No information avaliable

Humans and other mammals