STRZ

STRZ Brand names, STRZ Analogs

STRZ Brand Names Mixture

No information avaliable

STRZ Chemical_Formula

C₈H₁₅N₃O₇

STRZ RX_link

http://www.rxlist.com/cgi/generic/zanosar.htm

STRZ fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=215

STRZ msds (material safety sheet)

STRZ Synthesis Reference

No information avaliable

STRZ Molecular Weight

265.221 g/mol

STRZ Melting Point

115 ^oC

STRZ H₂O Solubility

5070 mg/L

STRZ State

Solid

STRZ LogP

-2.958

STRZ Dosage Forms

Powder for solution

STRZ Indication

For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

STRZ Pharmacology

Streptozocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.

STRZ Absorption

Poor oral absorption (17-25%)

STRZ side effects and Toxicity

Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity.

STRZ Patient Information