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SNL Brand names, SNL Analogs

SNL Brand Names Mixture

  • No information avaliable

SNL Chemical_Formula

C33H30N4O2

SNL RX_link

http://www.rxlist.com/cgi/generic2/telmisartan.htm

SNL fda sheet

SNL FDA

SNL msds (material safety sheet)

SNL MSDS

SNL Synthesis Reference

No information avaliable

SNL Molecular Weight

514.617 g/mol

SNL Melting Point

261-263oC

SNL H2O Solubility

Practically insoluble

SNL State

Solid

SNL LogP

7.245

SNL Dosage Forms

Tablets

SNL Indication

For the treatment of hypertension.

SNL Pharmacology

Telmisartan is an orally active nonpeptide angiotensin II antagonist that acts on the AT1 receptor subtype. New studies suggest that telmisartan may also have PPARγ agonistic properties that could potentially confer beneficial metabolic effects. This observation is currently being explored in clinical trials. Angiotensin II is formed from angiotensin I in a reaction catalyzed by angiotensin-converting enzyme (ACE, kininase II). Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium. Telmisartan works by blocking the vasoconstrictor and aldosterone secretory effects of angiotensin II.

SNL Absorption

Absolute bioavailability depends on dosage. Food slightly decreases the bioavailability (a decrease of about 6% is seen when the 40-mg dose is administered with food).

SNL side effects and Toxicity

Intravenous LD50 in rats is 150-200 mg/kg in males and 200 to 250 mg/kg in females. Acute oral toxicity is low: no deaths and no changes occurred in rats or dogs at 2000 mg/kg, the highest dose tested. Limited data are available with regard to overdosage in humans. The most likely manifestations of overdosage with telmisartan would be hypotension, dizziness and tachycardia; bradycardia could occur from parasympathetic (vagal) stimulation.

SNL Patient Information

SNL Organisms Affected

Humans and other mammals