Roxosul Tablets
Category
Roxosul Tablets Brand names, Roxosul Tablets Analogs
Roxosul Tablets Brand Names Mixture
- Pediazole (Erythromycin (Erythromycin Ethylsuccinate) + Sulfisoxazole Acetyl)
- Renazone Plus Tab (Ammonium Chloride + Atropine Sulfate + Hyoscyamine Hydrobromide + Scopolamine Hydrobromide + Sulfisoxazole)
Roxosul Tablets Chemical_Formula
C11H13N3O3S
Roxosul Tablets RX_link
No information avaliable
Roxosul Tablets fda sheet
Roxosul Tablets msds (material safety sheet)
Roxosul Tablets Synthesis Reference
H. M. Wuest, M. Hoffer, U.S. pat. 2,430,094 (1947 to Hoffmann-La Roche)
Roxosul Tablets Molecular Weight
267.305 g/mol
Roxosul Tablets Melting Point
194 oC
Roxosul Tablets H2O Solubility
0.13 mg/ml (25 oC)
Roxosul Tablets State
Solid
Roxosul Tablets LogP
2.569
Roxosul Tablets Dosage Forms
Tablet; Oral suspension; Eye drops
Roxosul Tablets Indication
Treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Roxosul Tablets Pharmacology
Sulfisoxazole is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Roxosul Tablets Absorption
No information avaliable
Roxosul Tablets side effects and Toxicity
LD50=6800 mg/kg (Orally in mice)
Roxosul Tablets Patient Information
Roxosul Tablets Organisms Affected
Enteric bacteria and other eubacteria
