Ropinirole

Category

Ropinirole




Useful info

Ropinirole Brand names, Ropinirole Analogs

Ropinirole Brand Names Mixture

  • No information avaliable

    • Ropinirole Chemical_Formula

    C16H24N2O

    Ropinirole RX_link

    http://www.rxlist.com/cgi/generic2/ropinirole.htm

    Ropinirole fda sheet

    Ropinirole FDA

    Ropinirole msds (material safety sheet)

    Ropinirole MSDS

    Ropinirole Synthesis Reference

    No information avaliable

    Ropinirole Molecular Weight

    260.375 g/mol

    Ropinirole Melting Point

    243-250 oC

    Ropinirole H2O Solubility

    133 mg/mL

    Ropinirole State

    Solid

    Ropinirole LogP

    2.72

    Ropinirole Dosage Forms

    Tablet (0.25 mg, 0.5 mg, 1 mg, 2 mg, 4 mg or 5 mg)

    Ropinirole Indication

    For the treatment of the signs and symptoms of idiopathic Parkinson's disease. Also used for the treatment of restless legs syndrome.

    Ropinirole Pharmacology

    Ropinirole is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes. The relevance of D3 receptor binding in Parkinson's disease is unknown. The mechanism of ropinirole-induced postural hypotension is presumed to be due to a D2 -mediated blunting of the noradrenergic response to standing and subsequent decrease in peripheral vascular resistance.

    Ropinirole Absorption

    Absolute bioavailability is 55%, indicating a first pass effect. Food does not affect the extent of absorption.

    Ropinirole Toxicity

    Symptoms of overdose include agitation, chest pain, confusion, drowsiness, facial muscle movements, grogginess, increased jerkiness of movement, symptoms of low blood pressure (dizziness, light-headedness)upon standing, nausea, and vomiting.

    Ropinirole Patient Information

    No information avaliable

    Ropinirole Organisms Affected

    Humans and other mammals