Quinazil
Quinazil Brand names, Quinazil Analogs
Quinazil Brand Names Mixture
- No information avaliable
Quinazil Chemical_Formula
C25H30N2O5
Quinazil RX_link
http://www.rxlist.com/cgi/generic/quinap.htm
Quinazil fda sheet
Quinazil msds (material safety sheet)
Quinazil Synthesis Reference
M. L. Hoefle, S. Klutchko, U.S. Pat. 4,344,949 (1982)
Quinazil Molecular Weight
438.516 g/mol
Quinazil Melting Point
120-130oC
Quinazil H2O Solubility
1 mg/L
Quinazil State
Solid
Quinazil LogP
3.384
Quinazil Dosage Forms
Tablets
Quinazil Indication
For the treatment of hypertension and chronic heart failure.
Quinazil Pharmacology
Quinapril, an angiotensin-converting enzyme (ACE) inhibitor, is used to treat hypertension and heart failure. Like ramipril, quinapril is a prodrug that, upon deesterification, is converted to the active metabolite quinaprilat. The effect of quinapril in hypertension and in congestive heart failure (CHF) appears to result primarily from the inhibition of circulating and tissue ACE activity, thereby reducing angiotensin II formation.
Quinazil Absorption
Following oral administration, peak plasma quinapril concentrations are observed within one hour. Based on recovery of quinapril and its metabolites in urine, the extent of absorption is at least 60%. The rate and extent of quinapril absorption are diminished moderately (approximately 25-30%) when ACCUPRIL tablets are administered during a high-fat meal.
Quinazil side effects and Toxicity
Overdose may lead to severe hypotension. LD50=1739mg/kg (orally in mice).
Quinazil Patient Information
Quinazil Organisms Affected
Humans and other mammals
