Pyridoxine hydrochloride
Category
Pyridoxine hydrochloride Brand names, Pyridoxine hydrochloride Analogs
Pyridoxine hydrochloride Brand Names Mixture
Pyridoxine hydrochloride Chemical_Formula
C8H11NO3
Pyridoxine hydrochloride RX_link
No information avaliable
Pyridoxine hydrochloride fda sheet
Pyridoxine hydrochloride msds (material safety sheet)
Pyridoxine hydrochloride Synthesis Reference
No information avaliable
Pyridoxine hydrochloride Molecular Weight
169.178 g/mol
Pyridoxine hydrochloride Melting Point
207 oC
Pyridoxine hydrochloride H2O Solubility
2.2E+005 mg/L
Pyridoxine hydrochloride State
Solid
Pyridoxine hydrochloride LogP
-0.784
Pyridoxine hydrochloride Dosage Forms
Capsules
Pyridoxine hydrochloride Indication
For the treatment of vitamin B6 deficiency and for the prophylaxis of isoniazid-induced peripheral neuropathy.
Pyridoxine hydrochloride Pharmacology
Vitamin B6 (pyridoxine) is a water-soluble vitamin used in the prophylaxis and treatment of vitamin B6 deficiency and peripheral neuropathy in those receiving isoniazid (isonicotinic acid hydrazide, INH). Vitamin B6 has been found to lower systolic and diastolic blood pressure in a small group of subjects with essential hypertension. Hypertension is another risk factor for atherosclerosis and coronary heart disease. Another study showed pyridoxine hydrochloride to inhibit ADP- or epinephrine-induced platelet aggregation and to lower total cholesterol levels and increase HDL-cholesterol levels, again in a small group of subjects. Vitamin B6, in the form of pyridoxal 5'-phosphate, was found to protect vascular endothelial cells in culture from injury by activated platelets. Endothelial injury and dysfunction are critical initiating events in the pathogenesis of atherosclerosis. Human studies have demonstrated that vitamin B6 deficiency affects cellular and humoral responses of the immune system. Vitamin B6 deficiency results in altered lymphocyte differentiation and maturation, reduced delayed-type hypersensitivity (DTH) responses, impaired antibody production, decreased lymphocyte proliferation and decreased interleukin (IL)-2 production, among other immunologic activities.
Pyridoxine hydrochloride Absorption
Readily absorbed
Pyridoxine hydrochloride side effects and Toxicity
Oral Rat LD50 = 4 gm/kg. Toxic effects include convulsions, dyspnea, hypermotility, diarrhea, ataxia and muscle weakness.
Pyridoxine hydrochloride Patient Information
No information avaliable
Pyridoxine hydrochloride Organisms Affected
Humans and other mammals
