Protolipan

Protolipan Brand names, Protolipan Analogs

Protolipan Brand Names Mixture

No information avaliable

Protolipan Chemical_Formula

C₂₀H₂₁ClO₄

Protolipan RX_link

http://www.rxlist.com/cgi/generic3/fenofibrate.htm

Protolipan fda sheet

Protolipan FDA

Protolipan msds (material safety sheet)

Protolipan MSDS

Protolipan Synthesis Reference

No information avaliable

Protolipan Molecular Weight

360.831 g/mol

Protolipan Melting Point

80.5 °C

Protolipan H₂O Solubility

0.25mg/ml at 25 °C

Protolipan State

Solid

Protolipan LogP

5.575

Protolipan Dosage Forms

Capsule; Tablet

Protolipan Indication

For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)

Protolipan Pharmacology

Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.

Protolipan Absorption

Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide

Protolipan side effects and Toxicity

LD₅₀=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.

Protolipan Patient Information