Prostin VR Pediatric
Prostin VR Pediatric Brand names, Prostin VR Pediatric Analogs
Prostin VR Pediatric Brand Names Mixture
- No information avaliable
Prostin VR Pediatric Chemical_Formula
C20H34O5
Prostin VR Pediatric RX_link
http://www.rxlist.com/cgi/generic/alprostadil.htm
Prostin VR Pediatric fda sheet
Prostin VR Pediatric msds (material safety sheet)
Prostin VR Pediatric Synthesis Reference
No information avaliable
Prostin VR Pediatric Molecular Weight
354.481 g/mol
Prostin VR Pediatric Melting Point
115 - 116 oC
Prostin VR Pediatric H2O Solubility
26.7 mg/L
Prostin VR Pediatric State
Solid
Prostin VR Pediatric LogP
2.983
Prostin VR Pediatric Dosage Forms
Liquid; Powder for solution; Solution; Suppository
Prostin VR Pediatric Indication
For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Prostin VR Pediatric Pharmacology
Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.
Prostin VR Pediatric Absorption
The absolute bioavailability of alprostadil has not been determined.
Prostin VR Pediatric side effects and Toxicity
Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.
Prostin VR Pediatric Patient Information
Prostin VR Pediatric Organisms Affected
Humans and other mammals
