Promate
Category
Promate Brand names, Promate Analogs
Promate Brand Names Mixture
Promate Chemical_Formula
C20H23NS
Promate RX_link
No information avaliable
Promate fda sheet
Promate msds (material safety sheet)
Promate Synthesis Reference
No information avaliable
Promate Molecular Weight
309.469 g/mol
Promate Melting Point
< 25 oC
Promate H2O Solubility
Soluble as HCl salt
Promate State
Liquid
Promate LogP
5.7
Promate Dosage Forms
Tablets (oral, 1 mg)
Promate Indication
Used for the symptomatic treatment of parkinsonism.
Promate Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Promate Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Promate side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Promate Patient Information
Promate Organisms Affected
Humans and other mammals
