Proguanil
Proguanil Brand names, Proguanil Analogs
Proguanil Brand Names Mixture
- No information avaliable
Proguanil Chemical_Formula
C11H16ClN5
Proguanil RX_link
No information avaliable
Proguanil fda sheet
Proguanil msds (material safety sheet)
Proguanil Synthesis Reference
No information avaliable
Proguanil Molecular Weight
253.731 g/mol
Proguanil Melting Point
129 oC
Proguanil H2O Solubility
156 mg/L
Proguanil State
Solid
Proguanil LogP
2.558
Proguanil Dosage Forms
Tablet
Proguanil Indication
For the causal prevention and suppression of malaria caused by susceptible strains of P. falciparum and other species of Plasmodium found in some geographical areas of the world.
Proguanil Pharmacology
Proguanil is a biguanide derivative that is converted to an active metabolite called cycloguanil pamoate. It exerts its antimalarial action by inhibiting parasitic dihydrofolate reductase enzyme. It has causal prophylactic and suppressive activity against P. falciparum and cures the acute infection. It is also effective in suppressing the clinical attacks of vivax malaria. However it is slower compared to 4-aminoquinolines.
Proguanil Absorption
Rapidly and well absorbed in humans following oral doses ranging from 50 to 500 mg.
Proguanil side effects and Toxicity
No information avaliable
Proguanil Patient Information
No information avaliable
Proguanil Organisms Affected
Plasmodium
