Prepidil

Prepidil Brand names, Prepidil Analogs

Prepidil Brand Names Mixture

No information avaliable

Prepidil Chemical_Formula

C₂₀H₃₂O₅

Prepidil RX_link

http://www.rxlist.com/cgi/generic2/dinoprostone.htm

Prepidil fda sheet

Prepidil msds (material safety sheet)

Prepidil MSDS

Prepidil Synthesis Reference

No information avaliable

Prepidil Molecular Weight

352.465 g/mol

Prepidil Melting Point

67 ^oC

Prepidil H₂O Solubility

58.1 mg/L

Prepidil State

Solid

Prepidil LogP

1.949

Prepidil Dosage Forms

Gel; Insert (suppository containing 20 mg of dinoprostone); Tablet

Prepidil Indication

For the termination of pregnancy from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period. Also for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period, and also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

Prepidil Pharmacology

Dinoprostone is equivalent to prostaglandin E2 (PGE2). It stimulates labor and delivery and thus terminates pregnancy. Dinoprostone is also capable of stimulating the smooth muscle of the gastrointestinal tract of man. This activity may be responsible for the vomiting and/or diarrhea that is not uncommon when dinoprostone is used to terminate pregnancy.

Prepidil Absorption

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Prepidil side effects and Toxicity

Oral, mouse: LD₅₀ = 750 mg/kg; Oral, rat: LD₅₀ = 500 mg/kg.

Prepidil Patient Information