Phosphonomycin
Phosphonomycin Brand names, Phosphonomycin Analogs
Phosphonomycin Brand Names Mixture
- Micardis Plus (Hydrochlorothiazide + Telmisartan)
Phosphonomycin Chemical_Formula
C3H7O4P
Phosphonomycin RX_link
http://www.rxlist.com/cgi/generic2/fosfomycin.htm
Phosphonomycin fda sheet
Phosphonomycin msds (material safety sheet)
Phosphonomycin Synthesis Reference
No information avaliable
Phosphonomycin Molecular Weight
138.059 g/mol
Phosphonomycin Melting Point
94 oC
Phosphonomycin H2O Solubility
50 mg/mL (Sodium salt)
Phosphonomycin State
Solid
Phosphonomycin LogP
-0.912
Phosphonomycin Dosage Forms
Powder
Phosphonomycin Indication
For the treatment of uncomplicated urinary tract infections (acute cystitis) in women due to susceptible strains of Escherichia coli and Enterococcus faecalis.
Phosphonomycin Pharmacology
Fosfomycin is a broad spectrum antibiotic that concentrates in kidney and bladder and is used to treat uncomplicated urinary tract infections. Fosfomycin also reduces nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents.
Phosphonomycin Absorption
Fosfomycin tromethamine is rapidly absorbed following oral administration and converted to fosfomycin. Oral bioavailability under fasting conditions is 37%. When given with food, oral bioavailability is reduced to 30%
Phosphonomycin side effects and Toxicity
LD50>5 g/kg (rats). Side effects may include diarrhea
Phosphonomycin Patient Information
No information avaliable
Phosphonomycin Organisms Affected
E. coli and other enteric bacteria
