Pertofran

• Antidepressants
• Norepinephrine-Reuptake Inhibitors
• ATC:N06AA01

• DMI
• Demethylimipramine
• Desimipramine
• Desimpramine
• Desipramin
• Desipramine Hcl
• Desmethylimipramine
• Dezipramine
• Dimethylimipramine
• Methylaminopropyliminodibenzyl
• Monodemethylimipramine
• Norimipramine
• Norpramin
• Norpramine
• Pentofran
• Pertofran
• Pertofrane
• Pertrofane
• Sertofran

• No information avaliable

C₁₈H₂₂N₂

http://www.rxlist.com/cgi/generic2/desipram.htm

Pertofran FDA

Pertofran MSDS

No information avaliable

266.381 g/mol

214-218 ^oC

No information avaliable

Solid

3.87

Tablet

For relief of symptoms in various depressive syndromes, especially endogenous depression.

Desipramine, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. Desipramine is used to treat depression, pain of neuropathic origin, attention_deficit hyperactivity disorder, functional enuresis in children, panic and phobic disorder, and to manage some eating disorders. Desipramine inhibits the re-uptake of noradrenaline at the noradrenergic nerve endings and the re-uptake of serotonin (5-hydroxy tryptamine) at the serotoninergic nerve endings in the central nervous system. These two effects are considered to be the likely base of the antidepressant effect of Desipramine. The drug also has a strong anticholinergic effect and serves as an antagonist on a1 and H1 receptors.

Desipramine hydrochloride is rapidly and almost completely absorbed from the gastrointestinal tract. 90.5% (range 73-92%) of desipramine binds to plasma proteins.

Male mice: LD₅₀ = 290 mg/kg, female rats: LD₅₀ = 320 mg/kg

No information avaliable

Humans and other mammals