Permax
Category
Permax Brand names, Permax Analogs
Permax Brand Names Mixture
No information avaliable
Permax Chemical_Formula
C19H26N2S
Permax RX_link
http://www.rxlist.com/cgi/generic2/pergol.htm
Permax fda sheet
Permax msds (material safety sheet)
Permax Synthesis Reference
No information avaliable
Permax Molecular Weight
314.489 g/mol
Permax Melting Point
207.5 oC
Permax H2O Solubility
No information avaliable
Permax State
Solid
Permax LogP
4.02
Permax Dosage Forms
Tablet
Permax Indication
Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson’s disease.
Permax Pharmacology
Pergolide is an ergot derivative dopamine receptor agonist at both D1 and D2 receptor sites. Pergolide is 10 to 1,000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In Parkinson’s disease, pergolide mesylate is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the nigrostriatal system.
Permax Absorption
Significant amount may be absorbed (evidence on bioavailability still lacking).
Permax Toxicity
Oral, rat LD50: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.
Permax Patient Information
Permax Organisms Affected
Humans and other mammals
