Pergolide
Category
Pergolide Brand names, Pergolide Analogs
Pergolide Brand Names Mixture
No information avaliable
Pergolide Chemical_Formula
C19H26N2S
Pergolide RX_link
http://www.rxlist.com/cgi/generic2/pergol.htm
Pergolide fda sheet
Pergolide msds (material safety sheet)
Pergolide Synthesis Reference
No information avaliable
Pergolide Molecular Weight
314.489 g/mol
Pergolide Melting Point
207.5 oC
Pergolide H2O Solubility
No information avaliable
Pergolide State
Solid
Pergolide LogP
4.02
Pergolide Dosage Forms
Tablet
Pergolide Indication
Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson’s disease.
Pergolide Pharmacology
Pergolide is an ergot derivative dopamine receptor agonist at both D1 and D2 receptor sites. Pergolide is 10 to 1,000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In Parkinson’s disease, pergolide mesylate is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the nigrostriatal system.
Pergolide Absorption
Significant amount may be absorbed (evidence on bioavailability still lacking).
Pergolide Toxicity
Oral, rat LD50: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.
Pergolide Patient Information
Pergolide Organisms Affected
Humans and other mammals
