Pergolida_[Inn-Spanish]

Category

Pergolida_[Inn-Spanish]




Useful info

Pergolida_[Inn-Spanish] Brand names, Pergolida_[Inn-Spanish] Analogs

Pergolida_[Inn-Spanish] Brand Names Mixture

  • No information avaliable

    • Pergolida_[Inn-Spanish] Chemical_Formula

    C19H26N2S

    Pergolida_[Inn-Spanish] RX_link

    http://www.rxlist.com/cgi/generic2/pergol.htm

    Pergolida_[Inn-Spanish] fda sheet

    Pergolida_[Inn-Spanish] FDA

    Pergolida_[Inn-Spanish] msds (material safety sheet)

    Pergolida_[Inn-Spanish] MSDS

    Pergolida_[Inn-Spanish] Synthesis Reference

    No information avaliable

    Pergolida_[Inn-Spanish] Molecular Weight

    314.489 g/mol

    Pergolida_[Inn-Spanish] Melting Point

    207.5 oC

    Pergolida_[Inn-Spanish] H2O Solubility

    No information avaliable

    Pergolida_[Inn-Spanish] State

    Solid

    Pergolida_[Inn-Spanish] LogP

    4.02

    Pergolida_[Inn-Spanish] Dosage Forms

    Tablet

    Pergolida_[Inn-Spanish] Indication

    Indicated as adjunctive treatment to levodopa/carbidopa in the management of the signs and symptoms of Parkinson’s disease.

    Pergolida_[Inn-Spanish] Pharmacology

    Pergolide is an ergot derivative dopamine receptor agonist at both D1 and D2 receptor sites. Pergolide is 10 to 1,000 times more potent than bromocriptine on a milligram per milligram basis in various in vitro and in vivo test systems. Pergolide mesylate inhibits the secretion of prolactin in humans; it causes a transient rise in serum concentrations of growth hormone and a decrease in serum concentrations of luteinizing hormone. In Parkinson’s disease, pergolide mesylate is believed to exert its therapeutic effect by directly stimulating postsynaptic dopamine receptors in the nigrostriatal system.

    Pergolida_[Inn-Spanish] Absorption

    Significant amount may be absorbed (evidence on bioavailability still lacking).

    Pergolida_[Inn-Spanish] Toxicity

    Oral, rat LD50: 15 mg/kg. Symptoms of overdose include nausea, vomiting, convulsions, decreased blood pressure, and CNS stimulation.

    Pergolida_[Inn-Spanish] Patient Information

    Pergolida_[Inn-Spanish] Organisms Affected

    Humans and other mammals