Pegvisomant
Pegvisomant Brand names, Pegvisomant Analogs
Pegvisomant Brand Names Mixture
- No information avaliable
Pegvisomant Chemical_Formula
C990H1532N262O300S7
Pegvisomant RX_link
http://www.rxlist.com/cgi/generic3/somavert.htm
Pegvisomant fda sheet
Pegvisomant msds (material safety sheet)
Pegvisomant Synthesis Reference
No information avaliable
Pegvisomant Molecular Weight
22129.0
Pegvisomant Melting Point
76 oC at pH 3.5 (Gomez-Orellana, I. et al., Protein Sci. 7:1352-1358 (1998).
Pegvisomant H2O Solubility
No information avaliable
Pegvisomant State
Liquid
Pegvisomant LogP
-0.411
Pegvisomant Dosage Forms
Solution (Subcutaneous Injection); Powder
Pegvisomant Indication
For treatment of acromegaly
Pegvisomant Pharmacology
Somavert is used for the treatment of acromegaly, which arises from excessive IGF-1 levels. Somavert selectively binds to growth hormone (GH) receptors on cell surfaces, where it blocks the binding of endogenous GH, and thus interferes with GH signal transduction. Inhibition of GH action results in decreased serum concentrations of insulin-like growth factor-I (IGF-I), and IGF binding protein-3 (IGFBP-3). This reduces the symptoms of acromegaly.
Pegvisomant Absorption
No information avaliable
Pegvisomant side effects and Toxicity
No information avaliable
Pegvisomant Patient Information
BIOD00044.html
Pegvisomant Organisms Affected
Humans and other mammals
