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PCB Brand names, PCB Analogs

PCB Brand Names Mixture

  • No information avaliable

PCB Chemical_Formula

C12H19N3O

PCB RX_link

http://www.rxlist.com/cgi/generic3/procarb.htm

PCB fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

PCB msds (material safety sheet)

PCB MSDS

PCB Synthesis Reference

No information avaliable

PCB Molecular Weight

221.299 g/mol

PCB Melting Point

223 oC

PCB H2O Solubility

1420 mg/L

PCB State

Solid

PCB LogP

1.234

PCB Dosage Forms

Capsule

PCB Indication

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

PCB Pharmacology

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

PCB Absorption

Procarbazine is rapidly and completely absorbed.

PCB side effects and Toxicity

LD50=785 mg/kg (orally in rats)

PCB Patient Information

PCB Organisms Affected

Humans and other mammals