P-Aminosalicylic Acid

P-Aminosalicylic Acid Brand names, P-Aminosalicylic Acid Analogs

P-Aminosalicylic Acid Brand Names Mixture

No information avaliable

P-Aminosalicylic Acid Chemical_Formula

C₇H₇NO₃

P-Aminosalicylic Acid RX_link

http://www.rxlist.com/cgi/generic2/paser.htm

P-Aminosalicylic Acid fda sheet

P-Aminosalicylic Acid msds (material safety sheet)

P-Aminosalicylic_Acid MSDS

P-Aminosalicylic Acid Synthesis Reference

Biniecki S., et al. Acta Pol Pharm. 1967;24(5):469-73

P-Aminosalicylic Acid Molecular Weight

153.135 g/mol

P-Aminosalicylic Acid Melting Point

150.5 ^oC

P-Aminosalicylic Acid H₂O Solubility

1690 mg/L

P-Aminosalicylic Acid State

Solid

P-Aminosalicylic Acid LogP

1.012

P-Aminosalicylic Acid Dosage Forms

Packet of coated granules

P-Aminosalicylic Acid Indication

For the treatment of tuberculosis

P-Aminosalicylic Acid Pharmacology

Aminosalicylic acid is an anti-mycobacterial agent used with other anti-tuberculosis drugs (most often isoniazid) for the treatment of all forms of active tuberculosis due to susceptible strains of tubercle bacilli. The two major considerations in the clinical pharmacology of aminosalicylic acid are the prompt production of a toxic inactive metabolite under acid conditions and the short serum half life of one hour for the free drug. Aminosalicylic acid is bacteriostatic against Mycobacterium tuberculosis (prevents the multiplying of bacteria without destroying them). It also inhibits the onset of bacterial resistance to streptomycin and isoniazid.

P-Aminosalicylic Acid Absorption

No information avaliable

P-Aminosalicylic Acid side effects and Toxicity

LD₅₀=4 gm/kg (orally in mice); LD₅₀=3650 mg/kg (orally in rabbits)

P-Aminosalicylic Acid Patient Information

P-Aminosalicylic Acid Organisms Affected

Mycobacteria