Orphenadrine Citrate

Orphenadrine Citrate Brand names, Orphenadrine Citrate Analogs

Orphenadrine Citrate Brand Names Mixture

No information avaliable

Orphenadrine Citrate Chemical_Formula

C₁₈H₂₃NO

Orphenadrine Citrate RX_link

http://www.rxlist.com/cgi/generic/orphen.htm

Orphenadrine Citrate fda sheet

Orphenadrine_Citrate FDA

Orphenadrine Citrate msds (material safety sheet)

Orphenadrine_Citrate MSDS

Orphenadrine Citrate Synthesis Reference

No information avaliable

Orphenadrine Citrate Molecular Weight

269.381 g/mol

Orphenadrine Citrate Melting Point

156-157 ^oC

Orphenadrine Citrate H₂O Solubility

Sparingly soluble in water

Orphenadrine Citrate State

Solid

Orphenadrine Citrate LogP

4.034

Orphenadrine Citrate Dosage Forms

Tablet (extended-release)

Orphenadrine Citrate Indication

Indicated for the treatment of Parkinson's disease.

Orphenadrine Citrate Pharmacology

Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.

Orphenadrine Citrate Absorption

Orphenadrine is almost completely absorbed in the gastrointestinal tract.

Orphenadrine Citrate side effects and Toxicity

Oral, mouse LD₅₀ = 100 mg/kg; oral, rat LD₅₀ = 255 mg/kg

Orphenadrine Citrate Patient Information