Orix

Orix Brand names, Orix Analogs

Orix Brand Names Mixture

No information avaliable

Orix Chemical_Formula

C₁₇H₁₈N₂O₆

Orix RX_link

http://www.rxlist.com/cgi/generic2/nifedip.htm

Orix fda sheet

Orix FDA

Orix msds (material safety sheet)

Orix MSDS

Orix Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Orix Molecular Weight

346.335 g/mol

Orix Melting Point

172 - 174 ^oC

Orix H₂O Solubility

Insoluble

Orix State

Solid

Orix LogP

2.343

Orix Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Orix Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Orix Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Orix Absorption

Rapidly and fully absorbed following oral administration.

Orix side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD₅₀=494 mg/kg (orally in mice); LD₅₀=1022 mg/kg (orally in rats)

Orix Patient Information

Orix Organisms Affected

Humans and other mammals