Ophtho-Dipivefrin

• Ophthalmologicals
• Sympathomimetics
• ATC:S01EA02

• AKPro
• DPE
• Dipivefrin HCL
• Dipivefrin [USAN]
• Dipivefrina [INN-Spanish]
• Dipivefrine
• Dipivefrinum [INN-Latin]
• Ophtho-Dipivefrin
• Propine
• Propine C Cap B.I.D.

• No information avaliable

C₁₉H₂₉NO₅

http://www.rxlist.com/cgi/generic2/dipivefrin.htm

Ophtho-Dipivefrin FDA

Ophtho-Dipivefrin MSDS

No information avaliable

351.437 g/mol

No information avaliable

Freely soluble as HCl salt

Solid

4.354

Drops; Liquid; Solution

Used as initial therapy for the control of intraocular pressure in chronic open-angle glaucoma.

Dipivefrin is a member of a class of drugs known as prodrugs. Prodrugs are usually not active in themselves and require biotransformation to the parent compound before therapeutic activity is seen. These modifications are undertaken to enhance absorption, decrease side effects and enhance stability and comfort, thus making the parent compound a more useful drug. Enhanced absorption makes the prodrug a more efficient delivery system for the parent drug because less drug will be needed to produce the desired therapeutic response. Dipivefrin is a prodrug of epinephrine formed by the diesterification of epinephrine and pivalic acid. The addition of pivaloyl groups to the epinephrine molecule enhances its lipophilic character and, as a consequence, its penetration into the anterior chamber.

Well absorbed following occular administration.

Oral LD₅₀ in rat is 183 mg/kg.

No information avaliable

Humans and other mammals