O-Methyldiphenhydramine
O-Methyldiphenhydramine Brand names, O-Methyldiphenhydramine Analogs
O-Methyldiphenhydramine Brand Names Mixture
- No information avaliable
O-Methyldiphenhydramine Chemical_Formula
C18H23NO
O-Methyldiphenhydramine RX_link
http://www.rxlist.com/cgi/generic/orphen.htm
O-Methyldiphenhydramine fda sheet
O-Methyldiphenhydramine msds (material safety sheet)
O-Methyldiphenhydramine Synthesis Reference
No information avaliable
O-Methyldiphenhydramine Molecular Weight
269.381 g/mol
O-Methyldiphenhydramine Melting Point
156-157 oC
O-Methyldiphenhydramine H2O Solubility
Sparingly soluble in water
O-Methyldiphenhydramine State
Solid
O-Methyldiphenhydramine LogP
4.034
O-Methyldiphenhydramine Dosage Forms
Tablet (extended-release)
O-Methyldiphenhydramine Indication
Indicated for the treatment of Parkinson's disease.
O-Methyldiphenhydramine Pharmacology
Orphenadrine is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute painful musculoskeletal conditions. Orphenadrine is an anticholinergic with a predominantly central effect and only a weak peripheral effect. In addition, it has mild antihistaminic and local anaesthetic properties. Parkinson's syndrome is the consequence of a disturbed balance between cholinergic and dopaminergic neurotransmission in the basal ganglia caused by a decrease in dopamine. Orphenadrine restores the physiological equilibrium and has a favourable effect on the rigidity and tremor of Parkinson's disease and Parkinsonian syndromes. The effect is somewhat less on bradykinesia.
O-Methyldiphenhydramine Absorption
Orphenadrine is almost completely absorbed in the gastrointestinal tract.
O-Methyldiphenhydramine side effects and Toxicity
Oral, mouse LD50 = 100 mg/kg; oral, rat LD50 = 255 mg/kg
O-Methyldiphenhydramine Patient Information
No information avaliable
O-Methyldiphenhydramine Organisms Affected
Humans and other mammals
