Nifebene

Nifebene Brand names, Nifebene Analogs

Nifebene Brand Names Mixture

No information avaliable

Nifebene Chemical_Formula

C₁₇H₁₈N₂O₆

Nifebene RX_link

http://www.rxlist.com/cgi/generic2/nifedip.htm

Nifebene fda sheet

Nifebene FDA

Nifebene msds (material safety sheet)

Nifebene MSDS

Nifebene Synthesis Reference

Bossert, Vater, U.S. Pat. 3,485,847 (1969)

Nifebene Molecular Weight

346.335 g/mol

Nifebene Melting Point

172 - 174 ^oC

Nifebene H₂O Solubility

Insoluble

Nifebene State

Solid

Nifebene LogP

2.343

Nifebene Dosage Forms

Capsule; Tablet; Tablet (extended-release)

Nifebene Indication

For the management of vasospastic angina, chronic stable angina and hypertension.

Nifebene Pharmacology

Nifedipine, the prototype of the dihydropyridine class of calcium-channel antagonists, is similar to other dihydropyridines including amlodipine, felodipine, isradipine, and nicardipine. Nifedipine is used to treat Prinzmetal's angina, hypertension, and other vascular disorders such as Raynaud's phenomenon. By blocking the calcium channels, Nifedipine inhibits the spasm of the coronary artery and dilates the systemic arteries, results in a increase of myocardial oxygen supply and a decrease in systemic blood pressure.

Nifebene Absorption

Rapidly and fully absorbed following oral administration.

Nifebene side effects and Toxicity

Symptoms of overdose include dizziness, drowsiness, nausea, severe drop in blood pressure, slurred speech, and weakness. LD₅₀=494 mg/kg (orally in mice); LD₅₀=1022 mg/kg (orally in rats)

Nifebene Patient Information

Nifebene Organisms Affected

Humans and other mammals