Nebralin
Category
Nebralin Brand names, Nebralin Analogs
Nebralin Brand Names Mixture
Nebralin Chemical_Formula
C32H41NO2
Nebralin RX_link
http://www.rxlist.com/cgi/generic/terfen.htm
Nebralin fda sheet
Nebralin msds (material safety sheet)
Nebralin Synthesis Reference
A. A. Carr, C. R. Kinsolving, U.S. Pat. 3,878,217 (1975)
Nebralin Molecular Weight
471.673 g/mol
Nebralin Melting Point
146.5-148.5oC
Nebralin H2O Solubility
10 mg/L
Nebralin State
Solid
Nebralin LogP
7.784
Nebralin Dosage Forms
Oral tablets
Nebralin Indication
For the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Nebralin Pharmacology
Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine.
Nebralin Absorption
On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%
Nebralin side effects and Toxicity
Mild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)
Nebralin Patient Information
Nebralin Organisms Affected
Humans and other mammals
