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Natunalar Brand names, Natunalar Analogs

Natunalar Brand Names Mixture

  • No information avaliable

Natunalar Chemical_Formula

C12H19N3O

Natunalar RX_link

http://www.rxlist.com/cgi/generic3/procarb.htm

Natunalar fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=44

Natunalar msds (material safety sheet)

Natunalar MSDS

Natunalar Synthesis Reference

No information avaliable

Natunalar Molecular Weight

221.299 g/mol

Natunalar Melting Point

223 oC

Natunalar H2O Solubility

1420 mg/L

Natunalar State

Solid

Natunalar LogP

1.234

Natunalar Dosage Forms

Capsule

Natunalar Indication

For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.

Natunalar Pharmacology

Procarbazine is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Procarbazine is cell-phase specific for the S phase of cell division.

Natunalar Absorption

Procarbazine is rapidly and completely absorbed.

Natunalar side effects and Toxicity

LD50=785 mg/kg (orally in rats)

Natunalar Patient Information

Natunalar Organisms Affected

Humans and other mammals