Nallpen

Nallpen Brand names, Nallpen Analogs

Nallpen Brand Names Mixture

No information avaliable

Nallpen Chemical_Formula

C₃₃H₄₇NO₁₃

Nallpen RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Nallpen fda sheet

Nallpen msds (material safety sheet)

Nallpen Synthesis Reference

No information avaliable

Nallpen Molecular Weight

665.725 g/mol

Nallpen Melting Point

290 ^oC

Nallpen H₂O Solubility

4100 mg/L

Nallpen State

Solid

Nallpen LogP

0.495

Nallpen Dosage Forms

Ophthalmic suspension (5%)

Nallpen Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Nallpen Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Nallpen Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Nallpen side effects and Toxicity