Myelosanum, Busulphan en es it fr

Myelosanum, Busulphan Brand names, Myelosanum, Busulphan Analogs

Myelosanum, Busulphan Brand Names Mixture

  • None

Myelosanum, Busulphan Chemical_Formula

C6H14O6S2

Myelosanum, Busulphan RX_link

http://www.rxlist.com/cgi/generic2/busulfan.htm

Myelosanum, Busulphan fda sheet

Myelosanum,_Busulphan FDA

Myelosanum, Busulphan msds (material safety sheet)

Myelosanum,_Busulphan MSDS

Myelosanum, Busulphan Synthesis Reference

U.S. pat. 2,917,432(1959)

Myelosanum, Busulphan Molecular Weight

246.304 g/mol

Myelosanum, Busulphan Melting Point

287 oC

Myelosanum, Busulphan H2O Solubility

6.9E+004 mg/L

Myelosanum, Busulphan State

Solid

Myelosanum, Busulphan LogP

-0.52

Myelosanum, Busulphan Dosage Forms

Solution; Tablet

Myelosanum, Busulphan Indication

For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.

Myelosanum, Busulphan Pharmacology

Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Myelosanum, Busulphan Absorption

Completely absorbed from the gastrointestinal tract.

Myelosanum, Busulphan side effects and Toxicity

Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.

Myelosanum, Busulphan Patient Information

Myelosanum, Busulphan Organisms Affected

Humans and other mammals