Monobactam

• Anti-Bacterial Agents
• ATC:J01DF01

• AZT
• Azactam
• Aztreonam [USAN:BAN:INN:JAN]
• Aztreonamum [Latin]
• Corus 1020
• Dynabiotic
• Monobactam
• Primbactam

• No information avaliable

C₁₃H₁₇N₅O₈S₂

http://www.rxlist.com/cgi/generic4/azactaminj.htm

Monobactam FDA

Monobactam MSDS

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435.435 g/mol

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Insoluble

Solid

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Solution (plastic container containing a frozen, iso-osmotic, sterile, sodium-free, nonpyrogenic intravenous solution where each 50 mL of solution contains 1 g, or 2 g aztreonam)

For the treatment of the following infections caused by susceptible gram-negative microorganisms: urinary tract infections, lower respiratory tract infections, septicemia, skin and skin-structure infections, intra-abdominal infections, and gynecologic infections.

Aztreonam is a monocyclic beta-lactam antibiotic (a monobactam) originally isolated from Chromobacterium violaceum. Aztreonam exhibits potent and specific activity in vitro against a wide spectrum of gram-negative aerobic pathogens including Pseudomonas aeruginosa. It has no useful activity against gram-positive bacteria or anaerobes, but has very broad spectrum against gram-negative aerobes, including Pseudomonas aeruginosa. This has given it the nickname "the magic bullet for aerobic gram-negative bacteria". Aztreonam, unlike the majority of beta-lactam antibiotics, does not induce beta-lactamase activity and its molecular structure confers a high degree of resistance to hydrolysis by beta-lactamases (such as penicillinases and cephalosporinases) produced by most gram-negative and gram-positive pathogens; it is, therefore, usually active against gram-negative aerobic microorganisms that are resistant to antibiotics hydrolyzed by beta-lactamases. It is active against many strains that are multiply-resistant to other antibiotics, such as certain cephalosporins, penicillin, and aminoglycosides. Aztreonam maintains its antimicrobial activity over a pH range of 6 to 8 in vitro, as well as in the presence of human serum and under anaerobic conditions.

Less than 1% absorbed from the gastrointestinal tract following oral administration. Completely absorbed following intramuscular administration.

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Enteric bacteria and other eubacteria