Mitoxan

Category

Mitoxan




Useful info

Mitoxan Brand names, Mitoxan Analogs

Mitoxan Brand Names Mixture

  • No information avaliable

    • Mitoxan Chemical_Formula

    C7H15Cl2N2O2P

    Mitoxan RX_link

    http://www.rxlist.com/cgi/generic2/ifosfamide.htm

    Mitoxan fda sheet

    http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=95

    Mitoxan msds (material safety sheet)

    Mitoxan MSDS

    Mitoxan Synthesis Reference

    No information avaliable

    Mitoxan Molecular Weight

    261.085 g/mol

    Mitoxan Melting Point

    39-41 oC

    Mitoxan H2O Solubility

    3780 mg/L

    Mitoxan State

    Solid

    Mitoxan LogP

    -0.01

    Mitoxan Dosage Forms

    Powder for constitution and administration by intravenous infusion

    Mitoxan Indication

    For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.

    Mitoxan Pharmacology

    Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

    Mitoxan Absorption

    No information avaliable

    Mitoxan Toxicity

    LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).

    Mitoxan Patient Information

    No information avaliable

    Mitoxan Organisms Affected

    Humans and other mammals