Mitox
Mitox Brand names, Mitox Analogs
Mitox Brand Names Mixture
- No information avaliable
Mitox Chemical_Formula
C7H15Cl2N2O2P
Mitox RX_link
http://www.rxlist.com/cgi/generic2/ifosfamide.htm
Mitox fda sheet
Mitox msds (material safety sheet)
Mitox Synthesis Reference
No information avaliable
Mitox Molecular Weight
261.085 g/mol
Mitox Melting Point
39-41 oC
Mitox H2O Solubility
3780 mg/L
Mitox State
Solid
Mitox LogP
-0.01
Mitox Dosage Forms
Powder for constitution and administration by intravenous infusion
Mitox Indication
For third line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna.
Mitox Pharmacology
Ifosfamide selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of ifosfamide-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Mitox Absorption
No information avaliable
Mitox side effects and Toxicity
LD50 (mouse) = 390-1005 mg/kg, LD50 (rat) = 150-190 mg/kg. Side effects include nausea, vomiting and myelosuppression. Toxic effects include central nervous system toxicity (confusion, hallucinations) and urotoxic effects (cystitis, blood in urine).
Mitox Patient Information
No information avaliable
Mitox Organisms Affected
Humans and other mammals
