Mexitil

Mexitil Brand names, Mexitil Analogs

Mexitil Brand Names Mixture

No information avaliable

Mexitil Chemical_Formula

C₁₁H₁₇NO

Mexitil RX_link

http://www.rxlist.com/cgi/generic3/mexiletine.htm

Mexitil fda sheet

Mexitil FDA

Mexitil msds (material safety sheet)

Mexitil MSDS

Mexitil Synthesis Reference

No information avaliable

Mexitil Molecular Weight

179.259 g/mol

Mexitil Melting Point

203-205 ^oC

Mexitil H₂O Solubility

8.25 mg/mL

Mexitil State

Solid

Mexitil LogP

2.039

Mexitil Dosage Forms

Capsule (150 mg, 200 mg and 250 mg)

Mexitil Indication

For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.

Mexitil Pharmacology

Mexiletine is a local anesthetic, antiarrhythmic agent (Class Ib), structurally similar to lidocaine, but orally active. Mexiletine has fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. It shortens the action potential duration, reduces refractoriness, and decreases Vmax in partially depolarized cells with fast response action potentials. Mexiletine either does not change the action potential duration, or decreases the action potential duration.

Mexitil Absorption

Well absorbed (bioavailability 90%) from the gastrointenstinal tract.

Mexitil side effects and Toxicity

Symptoms of overdose include nausea, hypotension, sinus bradycardia, paresthesia, seizures, bundle branch block, AV heart block, asystole, ventricular tachyarrythmia, including ventricular fibrillation, cardiovascular collapse, and coma.

Mexitil Patient Information