Mevalotin
Mevalotin Brand names, Mevalotin Analogs
Mevalotin Brand Names Mixture
- No information avaliable
Mevalotin Chemical_Formula
C23H36O7
Mevalotin RX_link
http://www.rxlist.com/cgi/generic/pravast.htm
Mevalotin fda sheet
Mevalotin msds (material safety sheet)
Mevalotin Synthesis Reference
A. Terahara, M.Tanaka, U.S. Pat. 4,346,227(1982)
Mevalotin Molecular Weight
424.528 g/mol
Mevalotin Melting Point
326oC
Mevalotin H2O Solubility
2464mg/L
Mevalotin State
Solid
Mevalotin LogP
2.613
Mevalotin Dosage Forms
Tablet
Mevalotin Indication
For the treatment of hypercholesterolemia to reduce the risk of myocardial infarction.
Mevalotin Pharmacology
Pravastatin, an antilipemic agent, is used to treat primary hypercholesterolemia. Unlike lovastatin and simvastatin, pravastatin is relatively hydrophilic and does not require hydrolysis for activation.
Mevalotin Absorption
Average oral absorption of pravastatin is 34% and absolute bioavailability is 17%.
Mevalotin side effects and Toxicity
Rhabdomyolysis; LD50=mg/kg (orally in rat)
Mevalotin Patient Information
Patients should be advised to report promptly unexplained muscle pain, tenderness or weakness, particularly if accompanied by malaise or fever.
Mevalotin Organisms Affected
Humans and other mammals
