Methyl Hydantoin

• Anticonvulsants
• ATC:N03AB04

• Dilantin
• Dilantin-125
• Epiazin
• Epilan
• Fenantoin
• Gerot-Epilan
• Insulton
• Mephentoin
• Mesantoin
• Mesdontoin
• Mesontoin
• Methoin
• Methyl Hydantoin
• Methylphenetoin
• Metydan
• Phenantoin
• Phentytoin
• Phenylethylmethylhydantoin
• Phenytoin
• Sacerno
• Sedantional
• Sedantoin
• Sedantoinal
• Triantoin

• No information avaliable

C₁₂H₁₄N₂O₂

No information avaliable

No information avaliable

218.252 g/mol

135 ^oC

1270 mg/L

Solid

1.515

Tablet

For the treatment of refractory partial epilepsy.

Mephenytoin is an antiepileptic drug which can be useful in the treatment of epilepsy. The primary site of action appears to be the motor cortex where spread of seizure activity is inhibited. Possibly by promoting sodium efflux from neurons, mephenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of posttetanic potentiation at synapses. Loss of posttetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. Mephenytoin reduces the maximal activity of brain stem centers responsible for the tonic phase of tonic-clonic (grand mal) seizures.

No information avaliable

No information avaliable

Patient Information:

Discuss with your doctor about the risks of taking Mephenytoin. Mephenytoin may
pass into the breast milk. If you are breast feeding or have any other medical condition,
make sure you let the doctor know.
Alcohol and some other medications may affect the effect of Mephenytoin.
Do not change dose and dosing schedule without consulting your doctor.

Humans and other mammals