Methimazole
Category
Methimazole Brand names, Methimazole Analogs
Methimazole Brand Names Mixture
Methimazole Chemical_Formula
C4H6N2S
Methimazole RX_link
http://www.rxlist.com/cgi/generic3/methim.htm
Methimazole fda sheet
Methimazole msds (material safety sheet)
Methimazole Synthesis Reference
No information avaliable
Methimazole Molecular Weight
114.17 g/mol
Methimazole Melting Point
146 oC
Methimazole H2O Solubility
275 g/L
Methimazole State
Solid
Methimazole LogP
-0.34
Methimazole Dosage Forms
Tablet (5 or 10 mg)
Methimazole Indication
For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.
Methimazole Pharmacology
Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.
Methimazole Absorption
Rapid with an oral bioavailability of 93%.
Methimazole side effects and Toxicity
Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.
Methimazole Patient Information
Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.
Methimazole Organisms Affected
Humans and other mammals
