Methimazole en es it fr

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Methimazole
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Methimazole Brand names, Methimazole Analogs

Methimazole Brand Names Mixture

  • No information avaliable

Methimazole Chemical_Formula

C4H6N2S

Methimazole RX_link

http://www.rxlist.com/cgi/generic3/methim.htm

Methimazole fda sheet

Methimazole msds (material safety sheet)

Methimazole MSDS

Methimazole Synthesis Reference

No information avaliable

Methimazole Molecular Weight

114.17 g/mol

Methimazole Melting Point

146 oC

Methimazole H2O Solubility

275 g/L

Methimazole State

Solid

Methimazole LogP

-0.34

Methimazole Dosage Forms

Tablet (5 or 10 mg)

Methimazole Indication

For the treatment of hyperthyroidism, goiter, Graves disease and psoriasis.

Methimazole Pharmacology

Used in the treatment of hyperthyroidism or an overactive thyroid gland, methimazole inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Methimazole Absorption

Rapid with an oral bioavailability of 93%.

Methimazole side effects and Toxicity

Oral LD50 in rats is 2250 mg/kg. Symptoms of overdose include nausea, vomiting, epigastric distress, headache, fever, joint pain, pruritus, and edema. Aplastic anemia (pancy-topenia) or agranulocytosis may be manifested in hours to days. Less frequent events are hepatitis, nephrotic syndrome, exfoliative dermatitis, neuropathies, and CNS stimulation or depression.

Methimazole Patient Information

Patients should be instructed to report to their physicians any symptoms of agranulocytosis, such as fever or sore throat.

Methimazole Organisms Affected

Humans and other mammals